Guest blog by Megan Koscinski, MS, RD As GLP-1 medications like semaglutide and tirzepatide grow in popularity, many people are looking for safe, effective, over-the-counter (OTC) supplements that can support their results, ease side effects, and promote long-term well-being
11.1 What GLP-1 Therapy Does Not Do Current evidence does not support the claim that GLP-1 receptor agonists: Cause universal micronutrient depletion Directly impair intestinal absorption Mimic bariatric malabsorption Require blanket supplementation Intestinal anatomy remains intact
Emerging evidence suggests their neuroprotective effects in neurodegenerative disorders, particularly Alzheimers disease, as well as potential anti-tumor properties in various malignancies [7]
Initially developed for type 2 diabetes, they are now recognized for their broad impact on weight regulation, inflammation, cardiovascular health, and neuroprotectiondomains central to longevity and healthy aging
Those with primarily immune-driven (rather than inflammation-amplified) disease may see less benefit
Interestingly, daily peripheral exenatide administration induced a transient reduction in food intake, which regresses to baseline over time